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Invitrogen™ Human EGFR (ErbB1) [T790M, L858R], GST Tag Recombinant Protein

Código de producto. 15448693
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Cantidad:
100 μg
1 mg
Tamaño de la unidad:
1 miligramo
100 microgramos
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Código de producto. Cantidad unitSize
15448693 100 μg 100 microgramos
15418773 1 mg 1 miligramo
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Código de producto. 15448693 Proveedor Invitrogen™ N.º de proveedor PR8911A

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Descripción

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic

EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
TRUSTED_SUSTAINABILITY

Especificaciones

Concentración See Label
Para utilizar con (aplicación) Kinase Assay
Formulación 50 mM tris with 0.02% polysorbate 20, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
Peso molecular 90.6 kDa
Nombre Human EGFR (ErbB1) [T790M, L858R], GST Tag
Cantidad 100 μg
Estado normativo RUO - research use only
Nombre común EGFR (T790M, L858R Mutant)
Familia Quinasa EGF Receptor (ErbB) Kinase Family
Longitud de la proteína 668-1210; T790M, L858R
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Etiqueta de proteína GST-tag
Contenido y almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Sistema de expresión Insect cells
Formulario Liquid
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