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  4. Invitrogen™ Human CHEK2 (CHK2), His Tag Recombinant Protein

Invitrogen™ Human CHEK2 (CHK2), His Tag Recombinant Protein

Código de producto. 10003492
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Cantidad:
1 mg
Tamaño de la unidad:
1 miligramo
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Código de producto. 10003492

Marca: Invitrogen™ PV3983

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Descripción

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length.

CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso O96017
Concentración See Label
Para utilizar con (aplicación) Kinase Assay
Formulación 50mM tris with 50% glycerol, 0.04% Triton X-100, 150mM NaCl, 4mM DTT, 0.5mM EDTA and no preservative; pH 7.5
ID de gen (Entrez) 11200
Peso molecular 66 kDa
Nombre Human CHEK2 (CHK2), His Tag
Intervalo de pH 7.5
Método de purificación Purified
Cantidad 1 mg
Requisitos de almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Estado normativo RUO
Alias de gen CDS1; cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; Chek2; Chk2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; HuCds 1; HuCds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; Rad53; Rad53 homolog; RP11-436C9.1; Serine/threonine protein kinase Chk2; serine/threonine-protein kinase Chk2
Nombre común CHK2
Símbolo de gen Chek2
Familia Quinasa RAD53 Kinase Family
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Etiqueta de proteína His-tag
Secuencia Full length
Contenido y almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Grupo de cinasas Ser/Thr Kinases: CAMK Group
Condiciones de envío Dry Ice
Sistema de expresión Baculovirus
Forma de proteína Full Length
Formulario Liquid
Categoría de investigación Drug Development
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