Invitrogen™ Human CDK13/cyclin K, GST Tag, His Tag Recombinant Protein

Cyclin-dependent kinase 13 (CDK13) and Cyclin K form a complex that is integral to RNA processing and transcription regulation. CDK13, a member of the CDK family, is involved in the modulation of gene expression through phosphorylation of the C-terminal domain of RNA Polymerase II, affecting the transcription elongation phase. Cyclin K acts as a regulatory partner to CDK13, stabilizing its active conformation to efficiently catalyze its kinase functions. CDK13, along with Cyclin K, plays a pivotal role in RNA metabolism, influencing RNA splicing and 3' end processing, which are crucial for the synthesis of mature mRNA. Structural studies have characterized CDK13 as having unique features differentiating it from other CDKs, including distinctive domain arrangements that enable interaction with Cyclin K. The dysregulation of CDK13/Cyclin K activity has been observed in various diseases, including cancer, pointing to their importance as therapeutic targets. Research also highlights CDK13's involvement in maintaining cellular homeostasis, underscoring the complex network of interactions this kinase engages in beyond transcriptional control.