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CD45.2 Mouse anti-Mouse, FITC, Clone: 104, BD

Mouse Monoclonal Antibody

221.00€ - 510.00€

Especificaciones

Antígeno CD45.2
Clon 104
Concentración 0.5mg/mL
Aplicaciones Flow Cytometry
Clasificación Monoclonal
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15891419
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BD Biosciences
561874
0.1 mg
221.00€
cada uno
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Fecha estimada de envío: 04-07-2024
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15897378
Ver documentos Detalles de la promoción
BD Biosciences
553772
0.5 mg
510.00€
cada uno
Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío: 04-07-2024
para ver el stock
Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

The 104 clone has been reported to react with CD45 (Leukocyte Common Antigen) on all leukocytes of most mouse strains (eg, A, AKR, BALB/c, CBA/Ca, CBA/J, C3H/He, C57BL, C57BR, C57L, C58, DBA/1, DBA/2, NZB, SWR, 129). This alloantigen was originally named Ly-5.1, and this was the designation at the time that the antibody was characterized. The designation was later changed from Ly-5.1 to Ly-5.2 to conform with the convention that the .2 alloantigen designations be assigned to the C57BL/6 strain. mAb 104 has been reported not to react with leukocytes of the mouse strains expressing the CD45.1 alloantigen (eg, RIII, SJL/J, STS/A, and DA). CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. The 104 antibody has been reported to inhibit some responses of B cells, from mice expressing the CD45.2 alloantigen, to certain antigens and LPS. In addition, reduction of serum IgG levels and amelioration of autoimmune renal pathology were reported in mAb 104-treated systemic lupus erythematosus-prone mice.

Especificaciones

Especificaciones

CD45.2
0.5mg/mL
Monoclonal
Mouse
Mouse
B10.S mouse thymocytes and splenocytes
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
104
Flow Cytometry
FITC
RUO
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
IgG2a κ
Affinity Purified
Ly-5.2; T200; LCA; Leukocyte common antigen; Ptprc
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