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CD2 Mouse, anti-Human, PE, Clone: RPA-2.10, STEMCELL Technologies
Mouse Monoclonal Antibody
Marca: Stemcell Technologies 60007PE
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Descripción
- The RPA-2.10 antibody reacts with CD2, an ∼50 kDa type I transmembrane glycoprotein and a member of the immunoglobulin (Ig) superfamily; two Ig-like domains are located in its extracellular portion
- CD2 is broadly expressed on peripheral T and NK cells, dendritic cells, erythrocytes, most thymic T cells, subsets of thymic B cells, and on the endothelium
- CD2 expression appears early during T cell differentiation
- Aberrant expression has been observed in some lymphomas and myeloid leukemias
- CD2 is critically important for T cell activation and signaling, as well as lymphocyte adhesion
- The primary ligand for CD2 is CD58 (LFA-3) located on antigen-presenting cells, with additional ligands comprising CD15 (SSEA-1), CD48 and CD59
- Notably, the RPA-2.10 antibody blocks the mixed lymphocyte reaction
Especificaciones
| CD2 | |
| Monoclonal | |
| PE | |
| 100 Tests | |
| Baboon, Cynomolgus, Pig, Human | |
| T Cells |
| Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
| RPA-2.10 | |
| Mouse | |
| Primary | |
| IgG1 κ |
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Título del producto
CD2 Mouse, anti-Human, PE, Clone: RPA-2.10, STEMCELL Technologies
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