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c-Cbl Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marca: Proteintech 25818-1-AP-150UL
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Descripción
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.Especificaciones
| c-Cbl | |
| Polyclonal | |
| Unconjugated | |
| CBL | |
| C CBL, CBL, CBL2, c-Cbl, Proto oncogene c Cbl, RING finger protein 55, RNF55 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 12402, 867 | |
| -20°C | |
| Liquid |
| Immunoprecipitation, Western Blot | |
| 0.29 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| P22681, P22682 | |
| CBL | |
| c-Cbl Fusion Protein Ag23033 | |
| 150 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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