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Invitrogen™ Human BTK, His Tag Recombinant Protein

Código de producto. 11503447
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Cantidad:
100 μg
10 μg
Tamaño de la unidad:
10 microgramos
100 microgramos
Código de producto. Cantidad unitSize
11503447 10 μg 10 microgramos
12624770 100 μg 100 microgramos
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Código de producto. 11503447

Marca: Invitrogen™ PV3363

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Descripción

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length, Recombinant, Cytoplasmic.

Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso Q06187
Concentración See Label
Para utilizar con (aplicación) Kinase Assay
Formulación 50mM tris HCl with 150mM NaCl, 0.05% Triton X-100, 4mM DTT, 50% glycerol, 0.5mM EDTA and no preservative; pH 7.5
ID de gen (Entrez) 695
Peso molecular 81.3 kDa
Nombre Human BTK, His Tag
Intervalo de pH 7.5
Método de purificación Purified
Cantidad 10 μg
Requisitos de almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Estado normativo RUO
Alias de gen agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; IMD1; Kinase EMB; MGC126261; MGC126262; OTTHUMP00000023677; PSCTK1; RP1-164F3.2; truncated Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); xid; XLA; X-linked immune deficiency
Nombre común BTK
Símbolo de gen BTK
Familia Quinasa TEC Kinase Family
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Etiqueta de proteína His-tag
Secuencia Full length
Contenido y almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Entrada del ensayo Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity, Biochemical binding/kinetic
Grupo de cinasas Tyrosine Kinases
Condiciones de envío Dry Ice
Compatibilidad de sistemas LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
Entrada diana BTK
Gen diana Bruton agammaglobulinemia tyrosine kinase
Sistema de expresión Insect cells
Familia de proteínas Kinases & Inhibitors
Forma de proteína Full Length, Recombinant, Cytoplasmic
Formulario Liquid
Subtipo de proteína Cytoplasmic Tyrosine Kinases
Categoría de investigación Signal Transduction, Immunology
Grado de pureza o calidad 70% by SDS-PAGE
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