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Bcl-2 Antibody (8C8), DyLight 650, Novus Biologicals™

Código de producto. 18119103 Tienda Bio Techne Productos
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0.1 mL
Tamaño de la unidad:
0.10 ml
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18119103 0.1 mL 0.10 ml
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Código de producto. 18119103 Proveedor Novus Biologicals N.º de proveedor NBP233313C

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Beschreibung

Mouse Monoclonal Antibody

Bcl-2 Monoclonal specifically detects Bcl-2 in Human, Porcine, Primate, Monkey, Mouse (Negative), Rat (Negative) samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.
TRUSTED_SUSTAINABILITY

Spezifikation

Antígeno Bcl-2
Aplicaciones Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clasificación Monoclonal
Clon 8C8
Conjugado DyLight 650
Dilución Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1-5 μg/mL for coating, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Alias de gen apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, Bcl-2
Símbolos de los genes BCL2
Especie del huésped Mouse
Inmunógeno A synthetic peptide, aa41-54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein. (Uniprot: P10415 )
Peso molecular del antígeno 25 kDa
Método de purificación Protein A or G purified
Cantidad 0.1 mL
Estado normativo RUO
Disciplina de investigación Apoptosis, Autophagy, Cancer, Cellular Markers, Phospho Specific, Tumor Suppressors
Primario o secundario Primary
ID de gen (Entrez) 596
Especificidad de la prueba This antibody recognizes a protein of 25-26kDa, identified as the Bcl-2 lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of Bcl-2 lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2 lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express Bcl-2 protein and the small number in which the neoplastic cells are Bcl-2 negative.
Especies diana Human, Pig, Primate, Mouse (Negative), Rat (Negative)
Contenido y almacenamiento Store at 4C in the dark.
Formulario Purified
Isotype IgG1 κ
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