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VCP (Valosin Containing Protein) Mouse, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 612183

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15876129

  • 647.52€ / 1 set
Fecha estimada de envío: 24-02-2023
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Descripción

Descripción

ATPases that belong to the ATPase associated with different cellular activities (AAA) family are homo-oligomeric proteins that have roles in cell cycle regulation, protein degradation, organelle biogenesis, and vesicle mediated-protein transport. Valosin containing protein (VCP) is a AAA family member that is found as a hexamer in rat liver. In vitro, VCP catalyzes the hydrolysis of ATP, but this activity is distinct from classical transport ATPases. VCP protein is found primarily in the transitional elements between the rough and smooth ER (TER), but stimulation with EGF leads to VCP translocation to the nucleus. Antibodies to VCP can perturb cell-free formation of transition vesicles from isolated TER of rat liver, and can inhibit transfer of material from ER to Golgi in a reconstituted membrane system. VCP is phosphorylated after T-cell activation, and PTPH1 dephosphorylation of VCP correlates with suppression of cell growth. In addition, the N-terminal region of VCP binds to the DNA damage repair protein, BRCA1. Thus, VCP may have roles in both ER protein transport and nuclear function, which are important for cell growth and survival.

Immunofluorescence, Western Blotting

Especificaciones

Especificaciones

VCP (Valosin Containing Protein)
Monoclonal
250μg/mL
Valosin Containing Protein
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
18
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse VCP aa. 9-130
150 μg
Cell Biology
Rat, Mouse, Human, Chicken, Canine
IgG1
Videos
SDS
Documentos

Documentos

Certificados
Ofertas especiales

Ofertas especiales

For Research Use Only.