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Transferrin Receptor Mouse anti-Human, Unlabeled, Clone: 2, BD

Mouse Monoclonal Antibody

343.00€ - 635.00€

Especificaciones

Antígeno Transferrin Receptor
Clon 2
Concentración 250μg/mL
Aplicaciones Western Blot
Clasificación Monoclonal
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15886099
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BD Biosciences
612125
150 μg
635.00€
1 set
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Fecha estimada de envío: 03-07-2024
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15876099
Ver documentos Detalles de la promoción
BD Biosciences
612124
50 μg Este artículo actualmente no está disponible o ha sido discontinuado.
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Descripción

Descripción

Iron acquisition is a prerequisite for cell proliferation. The transferrin receptor is the primary mode of iron uptake. This receptor mediates iron uptake through internalization and recycling of the iron carrying serum protein transferrin. Binding of transferrin to its receptor causes rapid internalization into an acidic intracellular compartment where iron dissociates from transferrin. Both the receptor and transferrin are then recycled through the exocytic pathway. The transferrin receptor is expressed in most cells and tissues, especially proliferating cells, and the receptor is expressed as a dimer of identical integral membrane proteins. Transferrin receptor mRNA expression is inversely proportional to iron availability, and this regulation occurs through post-transcriptional control of mRNA stability. Transferrin receptor mRNA contains iron responsive elements (IRE) that are bound by IRE-binding proteins (IRP). The RNA binding of IRPs is dependent on iron levels. Thus, iron deprivation leads to increased RNA binding, which masks the recognition site of endonucleases and stabilizes transferrin receptor mRNA.

Western Blotting

Especificaciones

Especificaciones

Transferrin Receptor
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
2
Western Blot
Unconjugated
RUO
Human
Human Transferrin Receptor aa. 517- 623
Primary
Store undiluted at -20°C.
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