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ATGL Polyclonal Antibody, Invitrogen™
Goat Polyclonal Antibody
Marca: Invitrogen PA518902
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Descripción
This antibody is predicted to react with bovine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.Especificaciones
ATGL | |
Polyclonal | |
Unconjugated | |
PNPLA2 | |
0610039C21Rik; 1110001C14Rik; adipose triglyceride lipase; ATGL; ATGL DESNUTRIN; calcium-independent phospholipase A2; Desnutrin; DKFZp667M109; FP17548; IPLA2 zeta; iPLA2zeta; IPLA2-zeta; mutant patatin-like phospholipase domain containing 2; patatin like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing protein 2; patatin-like phospholipase domain-containing protein 2; PEDF R; PEDF-R; pigment epithelium-derived factor; plpl; plpl2; Pnpla2; RGD1309044; transport-secretion protein; Transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS 2.2; TTS2; TTS2.2; TTS-2.2 | |
Goat | |
Ammonium sulfate precipitation | |
RUO | |
57104, 66853 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunocytochemistry, Western Blot | |
0.5 mg/mL | |
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
Q8BJ56, Q96AD5 | |
PNPLA2 | |
Synthetic peptide sequence (HFNSKDELIQAN) corresponding to the internal amino acids of PNPLA2 | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |