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Phospho-GABBR1 (Ser923) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA14729
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Descripción
This antibody is predicted to react with bovine, human, mouse and non-human primate based on 100% sequence homology. This antibody detects a band at ∽102 kDa, representing GABAb R1 protein phosphorylated at Ser923.
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.Especificaciones
Phospho-GABBR1 (Ser923) | |
Polyclonal | |
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5 | |
Q9WV18, Q9Z0U4 | |
GABBR1 | |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser923 of rat GABBR1 conjugated to KLH | |
100 μL | |
Primary | |
Mouse, Rat | |
Antibody | |
IgG |
Western Blot | |
Unconjugated | |
GABBR1 | |
bM573K1.1; bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); DAAP-188P13.3; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA(B) receptor; GABAB; GABA-B receptor 1; GABA-B receptor, R1 subunit; GABAB1; Gaba-b1; GABAbR1; GABA-BR1; GABA-B-R1; Gababr1 receptor; Gaba-b-r1a; Gaba-br1a receptor; GABA-BR1b receptor; Gabbr1; GABBR1-3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) B receptor 1; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid (GABA-B) receptor, 1; gamma-aminobutyric acid type B receptor subunit 1; GB1; GBR1; GPRC3A; HGB1a; OTTHUMP00000109099; OTTHUMP00000214725; seven transmembrane helix receptor | |
Rabbit | |
Affinity chromatography | |
RUO | |
54393, 81657 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |