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p120 Catenin Mouse, Unlabeled, Clone: 98, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610134

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15875279

  • 647.52€ / 1 set
Fecha estimada de envío: 17-02-2023
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Descripción

Descripción

The membrane associated protein p120 Catenin (pp120 (Src substrate); p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate β-catenin and γ-catenin proteins. This similarity is evidenced by its characteristic Arm domain that is composed of 42-amino acid motif repeats. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like β- and γ-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.

Host Species: Mouse
Clone: 98
Isotype: IgG1
Species Reactivity: Human
Immunogen: Mouse pp120 aa. 326-632
Formula Weight [Chemical]: 120kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Especificaciones

Especificaciones

p120 Catenin
Monoclonal
250μg/mL
pp120 (Src Substrate); p120cas
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
98
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse pp120 aa. 326-632
150 μg
Cell Biology
Rat, Mouse, Human, Chicken, Canine
IgG1
Videos
SDS
Documentos

Documentos

Certificados
Ofertas especiales

Ofertas especiales

For Research Use Only.