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RBL1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA130263
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Descripción
Recommended positive controls: SK-BR-3 and NIH / 3T3 lysate..
RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor.
Especificaciones
| RBL1 | |
| Polyclonal | |
| Unconjugated | |
| RBL1 | |
| 107 kDa retinoblastoma-associated protein; AW547426; CP107; DNA-binding protein RFX5; MGC40006; p107; pRb1; RB transcriptional corepressor like 1; Rbl1; Regulatory factor X 5; regulatory factor X, 5 (influences HLA class II expression); regulatory factor X5; retinoblastoma-like 1; retinoblastoma-like 1 (p107); retinoblastoma-like protein 1; RFX5 | |
| Rabbit | |
| purified | |
| RUO | |
| 19650, 5933, 680111 | |
| 4° C, do not freeze | |
| Liquid |
| Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot | |
| 0.2 mg/mL | |
| PBS with 0.2% gelatin and 0.1% sodium azide | |
| P28749, Q64701 | |
| RBL1 | |
| Synthetic peptide (Human) (C terminal). | |
| 1 mL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |