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Nek2 Mouse anti-Human, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610594

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15895529

  • 647.52€ / 1 set
Fecha estimada de envío: 02-03-2023
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Descripción

Descripción

Reversible protein phosphorylation is critical for progression through the cell cycle and mitosis. In Aspergillus nidulans, the nima gene (never itosis) encodes a protein kinase that is essential for mitosis. Three human genes (nek1, 2, and 3 [Nima-related kinase]) with significant homology to the A. nidulans nima have been reported. The nek2 gene encodes a protein of 445 amino acids and, like its fungal homolog, its expression is regulated throughout the cell cycle. In Hela cells, Nek2 activity and expression are low during M and G1 phases of the cell cycle. However, both parameters increase during S phase and mitosis. In addition, Nek2 phosphorylates protein substrates exclusively at serine and threonine residues. Thus, like its fungal homolog, Nek2 may be a crucial element in controlling the cell's entry into S phase and mitosis.

This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Especificaciones

Especificaciones

Nek2
Monoclonal
250μg/mL
Nima Related Kinase 2
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
20
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
150 μg
Cell Biology
Human
IgG1
Videos
SDS
Documentos

Documentos

Certificados
Ofertas especiales

Ofertas especiales

For Research Use Only.