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Nek2 Mouse anti-Human, Unlabeled, Clone: 20, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 610594
Detalles adicionales : Peso : 0.01000kg
Descripción
Reversible protein phosphorylation is critical for progression through the cell cycle and mitosis. In Aspergillus nidulans, the nima gene (never itosis) encodes a protein kinase that is essential for mitosis. Three human genes (nek1, 2, and 3 [Nima-related kinase]) with significant homology to the A. nidulans nima have been reported. The nek2 gene encodes a protein of 445 amino acids and, like its fungal homolog, its expression is regulated throughout the cell cycle. In Hela cells, Nek2 activity and expression are low during M and G1 phases of the cell cycle. However, both parameters increase during S phase and mitosis. In addition, Nek2 phosphorylates protein substrates exclusively at serine and threonine residues. Thus, like its fungal homolog, Nek2 may be a crucial element in controlling the cell's entry into S phase and mitosis.
This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
Especificaciones
| Nek2 | |
| Monoclonal | |
| 250μg/mL | |
| Nima Related Kinase 2 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
| Western Blot | |
| 20 | |
| Unconjugated | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| 150 μg | |
| Cell Biology | |
| Human | |
| IgG1 |
For Research Use Only.