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CD138 Mouse anti-Human, FITC, Clone: MI15, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 552723
Detalles adicionales : Peso : 0.02000kg
Descripción
Reacts with CD138 (Syndecan-1), an 85-92kDa single chain transmembrane protein, strongly expressed on multiple-myeloma-derived cell lines and malignant plasma cell populations. It is also expressed on pre-B cells, immature B cells, and plasma cells, but not on mature circulating B-lymphocytes. Syndecan-1 is a member of the family of transmemrane heparan sulfate proteoglycans. It is also expressed on some non-hematopoietic cells, including embryonic mesenchymal cells, vascular smooth muscle cells, endothelial and neural cells. CD138 binds to many extracellular matrix proteins through its heparan sulfate side-chains, like fibronectin, collagen types I, III, and V, tenascin, thrombospondin, and antithrombin III. It is considered an extracellular matrix receptor that may serve as a co-receptor for fibroblast growth factor and related molecules. Monoclonal antibody MI15 blocks the binding of clone B-B4 but not clone DL-101 (other anti-syndecan-1 antibodies) by flow cytometric analysis. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
Host Species: Mouse
Clone: MI15
Isotype: IgG1 κ
Species Reactivity: Human
Flow Cytometry
Especificaciones
| CD138 | |
| Monoclonal | |
| FITC | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Human U266 and XG-1 Myeloma Cell Lines | |
| 100 Tests | |
| Immunology | |
| Human | |
| IgG1 κ |
| Flow Cytometry | |
| MI15 | |
| Syndecan; SDC; Syndecan 1; SDC1; SYND1 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
For Research Use Only.