missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Acetylcholine Receptor α Mouse, Unlabeled, Clone: 26, BD
Mouse Monoclonal Antibody
459.19€
Especificaciones
| Antígeno | Acetylcholine Receptor α |
|---|---|
| Clon | 26 |
| Concentración | 250μg/mL |
| Aplicaciones | Western Blot |
| Clasificación | Monoclonal |
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|---|---|---|---|---|---|---|---|---|---|
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|
15835749
|
BD Biosciences
610989 |
150 μg |
Este artículo actualmente no está disponible o ha sido discontinuado. Ver la página del producto para posibles alternativas |
||||||
Descripción
Acetylcholine is an amine neurotransmitter at the neuromuscular junction. It is released from the presynaptic membrane of a cholinergic synapse into the synaptic cleft. It diffuses across the cleft and binds acetylcholine receptors (AChR) on the postsynaptic membrane. Receptor binding induces postsynaptic membrane depolarization and the generation of an action potential that produces effects such as muscle contraction. The AChR is a 250kDa pentameric complex of four transmembrane subunits in a stoichiometry of α2βγδ. In response to ligand binding, all subunits participate in the formation of an integral cation channel. However, the acetylcholine binding site is primarily within the α subunit. Myasthenia gravis (MG) is an autoimmune condition in which AchR levels are decreased. Autoantibodies bind and crosslink the AchRs leading to their internalization and degradation. This results in a decreased number of functional AChRs. Patients develop muscular weakness and some voluntary muscle fatigue. However, development of MG is also affected by genetic factors. One of the allelic forms of the AChRα gene appears to significantly contribute to MG susceptibility.
Immunofluorescence, Western Blotting
Especificaciones
| Acetylcholine Receptor α | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG2a | |
| Affinity Purified |
| 26 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Mouse, Rat | |
| Rat Acetylcholine Receptor α aa. 332-457 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.