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5-Lipoxygenase Mouse, Unlabeled, Clone: 33, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610695

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15885589

  • 543.78€ / 1 set
Fecha estimada de envío: 02-03-2023
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Descripción

Descripción

5-Lipoxygenase (5-LO) is the initial enzyme that converts arachidonic acid to leukotrienes, which are important inflammatory and vasoconstrictive metabolites. It is activated in response to a number of stimuli, such as differentiation and allergen challenges. The 5-LO gene, abundantly expressed in placenta, lung, and leukocytes, encodes a protein of 674 amino acids with an apparent molecular weight of 78kDa. 5-LO is a Ca2+ and ATP-dependent enzyme that translocates from the cytosol to either a nuclear or plasma membrane compartment following activation. A proline-rich domain of 5-LO (amino acids 566-577) has been identified as a binding site for the PTyr-binding protein, Grb2. This Grb2 site links tyrosine kinases with activation and redistribution of 5-LO. Furthermore, tyrosine kinase inhibitors increase the activity of 5-LO and block the enzyme's subcellular redistribution.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Especificaciones

Especificaciones

5-Lipoxygenase
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
and ≤0.09% sodium azide., glycerol, Aqueous buffered solution containing BSA
150 μg
Cell Biology
Rat, Mouse, Human, Chicken
IgG1
Western Blot
33
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Videos
SDS
Documentos

Documentos

Certificados
Ofertas especiales

Ofertas especiales

For Research Use Only.