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Eurofins DiscoverX Akt1/PKBα Protein, Unactive
Descripción
Akt1 is an oncogenic AGC kinase that plays a critical role in regulating many processes including cell survival, metabolism, proliferation, growth and angiogenesis. AKT activation relies on the PI3K pathway, and is recognized as a critical node in the pathway. The E17 hotspot is the most characterized of AKT1 mutations, and has been shown to result in activation of the protein. Mutations in AKT1 have also been shown to confer resistance to allosteric kinase inhibitors in vitro.
GenBank M63167. The recombinant protein contains the amino acid substitution S478G with respect to this accession number. This conflict is reported inEMBL BE 206796. The residue coordinates in the native sequence are given.
Especificaciones
Especificaciones
| Formulación | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 50% glycerol, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. |
| Peso molecular | 59 kDa |
| Cantidad | 250 μg |
| Especie | Human |
| Recombinante | Recombinant |
| Etiqueta de proteína | N-terminal 6His |
| Sistema de expresión | Recombinant enzyme expressed in Sf21 insect cells |
| Forma de proteína | Full-length |
| Grado de pureza o calidad | ≥65% |
| Expresión | Akt1/PKBa, unactive |
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