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Invitrogen™ ADAM10 Recombinant Rabbit Monoclonal Antibody (23GB3920), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Marca: Invitrogen™ MA552638
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Descripción
Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
Especificaciones
| ADAM10 | |
| Recombinant Monoclonal | |
| 0.6 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| O14672, Q10743 | |
| Adam10 | |
| A synthesized peptide derived from ADAM10 (700-748AA). | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
| Western Blot, Immunocytochemistry | |
| 23GB3920 | |
| Unconjugated | |
| Adam10 | |
| 1700031C13Rik; a disintegrin and metallopeptidase domain 10; a disintegrin and metalloprotease domain (ADAM) 10; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase; AD10; AD18; ADAM; ADAM 10; ADAM metallopeptidase domain 10; ADAM10; ADAMs; CD156c; CDw156; Disintegrin and metalloproteinase domain-containing protein 10; HsT18717; KUZ; kuzbanian; kuzbanian protein homolog; MADM; Mammalian disintegrin-metalloprotease; metalloendopeptidases; metalloproteinase; myelin-associated metalloproteinase; RAK | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 102, 29650 | |
| -20°C | |
| Liquid |
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