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Invitrogen™ ZO-1 Monoclonal Antibody (ZO1-1A12), Alexa Fluor™ 594
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Código de producto. 10616055
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Cantidad:
100 μg
Tamaño de la unidad:
cada uno
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10616055 100 μg cada uno
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Código de producto. 10616055 Proveedor Invitrogen™ N.º de proveedor 339194

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Mouse Monoclonal Antibody

ZO-1 Monoclonal Antibody for ELISA, ICC/IF, Western Blot

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
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Especificaciones

Antígeno ZO-1
Aplicaciones ELISA, Western Blot, Immunocytochemistry
Clasificación Monoclonal
Clon ZO1-1A12
Concentración 0.5 mg/mL
Conjugado Alexa Fluor 594
Formulación PBS with 4.0mg/mL BSA and 0.1% sodium azide; pH 7.4
génica TJP1
N.º de referencia del gen O97758, Q07157
Alias de gen DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Símbolos de los genes TJP1
Especie del huésped Mouse
Inmunógeno Human recombinant ZO-1 fusion protein encompassing amino acids 334-634.
Método de purificación Protein A
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 403752, 7082
Especies diana Human, Canine
Contenido y almacenamiento 4°C, store in dark
Tipo de producto Antibody
Formulario Liquid
Isotype IgG1 κ
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