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Invitrogen™ XAF1 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Marca:  Invitrogen™ PA584333

Código de producto. 16361285

  • 578.00€ / 100 microlitros

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Beskrivelse

Beskrivelse

Immunogen sequence: PVECKFCKLD MQLSKLELHE SYCGSRTELC QGCGQFIMHR MLAQHRDVCR SEQAQLGKGE RISAPEREIY CHYC Highest antigen sequence indentity to the following orthologs: Rat - 50%, Mouse - 48%.

The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines.
TRUSTED_SUSTAINABILITY
Tekniske data

Tekniske data

XAF1
Polyclonal
Unconjugated
XAF1
BIRC4 binding protein; BIRC4-binding protein; Birc4bp; F-box protein 39; Fbox39; HSXIAPAF1; novel TRAF-type zinc finger protein; XAF1; XIAP associated factor 1; XIAP associated factor-1; Xiapaf1; XIAP-associated factor 1
Rabbit
Antigen affinity chromatography
RUO
54739
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Immunocytochemistry
0.3 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q6GPH4
XAF1
Recombinant protein corresponding to Human XAF1. Recombinant protein control fragment (Product #RP-93312).
100 μL
Primary
Human
Antibody
IgG
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