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Invitrogen™ USP37 Polyclonal Antibody
Descripción
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). [UniProt].
Especificaciones
Especificaciones
| Antígeno | USP37 |
| Aplicaciones | Western Blot |
| Clasificación | Polyclonal |
| Concentración | 1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 |
| génica | Usp37 |
| N.º de referencia del gen | Q86T82, Q8C0R0 |
| Alias de gen | 4932415L06Rik; C330008N13Rik; Deubiquitinating enzyme 37; Kiaa1594; tmp_locus_50; ubiquitin carboxyl-terminal hydrolase 37; ubiquitin specific peptidase 37; ubiquitin specific peptidase 37-like; ubiquitin specific protease 37; ubiquitin thioesterase 37; ubiquitin thiolesterase 37; ubiquitin-specific-processing protease 37; USP37 |
| Símbolos de los genes | Usp37 |
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Título del producto
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