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Invitrogen™ UNC93B1 Polyclonal Antibody

Descripción
A suggested positive control is human heart tissue lysate. PA5-20510 can be used with blocking peptide PEP-0630.
The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
Especificaciones
Especificaciones
| Antígeno | UNC93B1 |
| Aplicaciones | Immunohistochemistry, Western Blot, Immunocytochemistry |
| Clasificación | Polyclonal |
| Concentración | 1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 0.02% sodium azide |
| génica | UNC93B1 |
| N.º de referencia del gen | Q8VCW4, Q9H1C4 |
| Alias de gen | hUNC93B1; IIAE1; Protein unc-93 homolog B1; UNC93; unc93 homolog B; unc-93 homolog B; unc93 homolog B1; unc-93 homolog B1 (C. elegans); unc-93 related protein; UNC93B; Unc93b1; Unc-93B1 |
| Símbolos de los genes | UNC93B1 |
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Título del producto
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