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TRMT12 Monoclonal Antibody (OTI8C7), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Marca: Origene Technologies TA809550
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Descripción
TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.Especificaciones
| TRMT12 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q53H54 | |
| TRMT12 | |
| Full length human recombit protein of human TRMT12 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| Western Blot | |
| OTI8C7 | |
| Unconjugated | |
| TRMT12 | |
| TRM12, TYW2 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 55039 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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