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Invitrogen™ TRIF Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA588150
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Descripción
Positive Samples: A-549, U-251MG, 22RV1, Mouse spleen, Mouse eye, Rat spleen; Cellular Location: Cytoplasmic vesicle, autophagosome Immunogen sequence: RPIDGVSDWS QGCSLRSTGS PASLASNLEI SQSPTMPFLS LHRSPHGPSK LCDDPQASLV PEPVPGGCQE PEEMSWPPSG EIASPPELPS SPPPGLPEVA P.
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Especificaciones
| TRIF | |
| Polyclonal | |
| Unconjugated | |
| TICAM1 | |
| AW046014; AW547018; hCG_39321; HSD34; IIAE6; MyD88-3; Proline-rich, vinculin and TIR domain-containing protein B; PRVTIRB; Putative NF-kappa-B-activating protein 502H; RNF36; TI; Ticam1; TICAM-1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; TIR-domain containing adaptor inducing interferon-beta; toll like receptor adaptor molecule 1; toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta; toll-interleukin I receptor domain containing adaptor molecule 1; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1; TRIF | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 106759, 148022, 363328 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot, Immunocytochemistry | |
| 0.79 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q80UF7, Q8IUC6 | |
| TICAM1 | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 180-280 of human TRIF / TICAM1 (NP_8915491). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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