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Invitrogen™ TREX2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA562906
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Descripción
Immunogen sequence: RAETFVFLDL EATGLPSVEP EIAELSLFAV HRSSLENPEH DESGALVLP Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.
TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.
Especificaciones
| TREX2 | |
| Polyclonal | |
| Unconjugated | |
| TREX2 | |
| 3'-5' exonuclease TREX2; 3'-5' exonuclease TREX2 long form; RGD1562245; Three prime repair exonuclease 2; Trex2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 11219 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.05 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q9BQ50 | |
| TREX2 | |
| Recombinant protein corresponding to Human TREX2. Recombinant protein control fragment (Product #RP-101552). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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