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PeproTech TRAIL-R2 (DR5) (soluble) Polyclonal Antibody, PeproTech®, Invitrogen™

Código de producto. 17855583
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Cantidad:
1 mg
100 μg
50 μg
Tamaño de la unidad:
1 miligramo
100 microgramos
50 microgramos
Código de producto. Cantidad unitSize
17855583 50 μg 50 microgramos
17835413 100 μg 100 microgramos
17845783 1 mg 1 miligramo
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Código de producto. 17855583

Marca: PeproTech 500P29950UG

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Descripción

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human sTRAIL Receptor-2. Anti-Human sTRAIL Receptor-2-specific antibody was purified by affinity chromatography employing an immobilized Human sTRAIL Receptor-2 matrix. Sandwich ELISA: To detect Human sTRAIL Receptor-2 by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human sTRAIL Receptor-2 (500-P299Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human sTRAIL Receptor-2. Western Blot: To detect hsTRAIL Receptor-2 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hsTRAIL Receptor-2 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno TRAIL-R2 (DR5) (soluble)
Aplicaciones ELISA, Western Blot
Clasificación Polyclonal
Concentración 0.1-1.0 mg/mL
Conjugado Unconjugated
Formulación PBS with no preservative
génica TNFRSF10B
N.º de referencia del gen O14763
Alias de gen apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL-R2; CD262; cytotoxic TRAIL receptor-2; death domain containing receptor for TRAIL/Apo-2L; death receptor 5; Dr5; dr-5; Fas-like protein; KILLER; KILLER/DR5; KILLER/DR5 TRAIL death-inducing receptor; Ly98; MK; p53-regulated DNA damage-inducible cell death receptor(killer); sCD262; soluble CD262; TNF receptor superfamily member 10b; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL receptor 2; TRAILR2; TRAIL-R2; TRICK2; TRICK2A; TRICK2B; TRICKB; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; UNQ160/PRO186; ZTNFR9
Símbolos de los genes TNFRSF10B
Especie del huésped Rabbit
Inmunógeno E.coli-derived Recombinant Human sTRAIL Receptor-2.
Método de purificación Antigen affinity chromatography
Cantidad 50 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 8795
Especies diana Human
Contenido y almacenamiento -20°C
Tipo de producto Antibody
Formulario Lyophilized
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