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Invitrogen™ TOX Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA5111709
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Descripción
Immunogen sequence: PNNQMPVTVS IANMAVSPPP PLQISPPLHQ HLNMQQHQPL TMQQPLGNQL PMQVQ Highest antigen sequence indentity to the following orthologs: Rat - 91%, Mouse - 93%.
TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.
Especificaciones
| TOX | |
| Polyclonal | |
| Unconjugated | |
| TOX | |
| 1700007F02Rik; KIAA0808; thymocyte selection associated high mobility group box; thymocyte selection-associated high mobility group box; thymocyte selection-associated high mobility group box protein TOX; thymocyte selection-associated HMG box; thymus high mobility group box protein TOX; TOX; TOX1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 9760 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| O94900 | |
| TOX | |
| Recombinant Protein corresonding to Human TOX. Recombinant protein control fragment (Product #RP-107914). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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