Invitrogen™ Tnfaip6 Polyclonal Antibody

Descripción

Positive Samples: Mouse brain Immunogen sequence: WGFKDGIFHN SIWLERAAGV YHREARSGKY KLTYAEAKAV CEFEGGHLAT YKQLEAARKI GFHVCAAGWM AKGRVGYPIV KPGPNCGFGK TGIIDYGIRL NRSERWDAYC YNPHAKECGG VFTDPKQIFK SPGFPNEYED NQICYWHIRL KYGQRIHLSF LDFDLEDDPG CLADYVEIYD SYDDVHGFVG RYCGDELPDD IISTGNVMTL KFLSDASVTA GGFQIKYVAM DPVSKSSQGK NTSTTSTGNK NFLAGRFSHL.

The TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNF alpha and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNF alpha, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-alpha-inhibitor (I alpha I)). TSG-6 potentiates the inhibitory effect of l alpha l on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and l alpha l can modulate the protease network and thus inhibit inflammation.