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Invitrogen™ TMEM59 Polyclonal Antibody

Descripción
Recommended positive controls: A431, mouse liver, rat kidney. Predicted reactivity: Mouse (95%), Rat (94%), Pig (96%), Chicken (83%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
Especificaciones
Especificaciones
| Antígeno | TMEM59 |
| Aplicaciones | Immunohistochemistry (Paraffin), Western Blot |
| Clasificación | Polyclonal |
| Concentración | 1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 |
| génica | TMEM59 |
| N.º de referencia del gen | Q9BXS4, Q9QY73 |
| Alias de gen | 1110001M20Rik; 3110046P06Rik; AI256529; C1orf8; D4Ertd20e; DCF1; dendritic cell factor 1; HSPC001; Liver membrane-bound protein; MTDCF1; ORF18; PRO195; RGD1310313; RP4-758J24.2; Tdcf1; Thymic dendritic cell-derived factor 1; TMEM59; Transmembrane protein 59; UNQ169; UNQ169/PRO195 |
| Símbolos de los genes | TMEM59 |
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Título del producto
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