Invitrogen™ UBIAD1 Polyclonal Antibody

Descripción

PA1-4378 detects the TERE1 protein in human samples. PA1-4378 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~37 kDa protein representing TERE1 in urothelial carcinoma. The PA1- 4378 immunogen is a synthetic peptide corresponding to residues P(32) E Q D R L P Q R S W R Q K(45) of human TERE1. There is 85% sequence identity to mouse and rat.

A novel gene designated TERE1, has a significant effect on the growth regulation in bladder cancer. The TERE1 gene maps to a chromosome locus that has been identified by loss of heterozygosity studies as a site of a putative tumor suppressor gene or genes for multiple tumor types including prostate carcinoma. Data suggest that TERE1 may be significant in prostate cancer growth regulation and the down regulation or absence of TERE1 may be an important component of the phenotype of advanced disease. Data also suggest a potential role for this gene product in the progression of bladder cancer.