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Descripción
TCF12, also known as HTF4, is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. TCF12 is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. TCF12, in combination with E2A, is required to block thymocyte proliferation prior to pre-TCR expression and is critical for proper T cell differentiation. Recent reports have shown that TCF12 is also a critical factor required for the development of invariant natural killer T cells.
Especificaciones
Especificaciones
| Antígeno | TCF12/HEB |
| Aplicaciones | Immunohistochemistry (Paraffin), Western Blot |
| Clasificación | Polyclonal |
| Concentración | 0.18 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| génica | TCF12 |
| N.º de referencia del gen | P51514, Q61286, Q99081 |
| Alias de gen | bHLHb20, DNA binding protein HTF4, E box binding protein, HEB, HsT17266, HTF4, TCF 12, TCF12, transcription factor 12, Transcription factor HTF 4 |
| Símbolos de los genes | TCF12 |
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Título del producto
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