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Invitrogen™ TAB1 Recombinant Rabbit Monoclonal Antibody (21H11L15)

Código de producto. 16321774
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
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16321774 100 μg 100 microgramos
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Código de producto. 16321774 Proveedor Invitrogen™ N.º de proveedor 703255

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Descripción

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Pig, Dog. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. It can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno TAB1
Aplicaciones Western Blot
Clasificación Recombinant Monoclonal
Clon 21H11L15
Concentración 0.5 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.09% sodium azide; pH 7.4
génica TAB1
N.º de referencia del gen Q15750, Q8CF89
Alias de gen 2310012M03Rik; 3'-Tab1; b2b449Clo; beta activated kinase-1 binding protein-1; MAP3K7IP1; MGC57664; mitogen activated protein kinase kinase kinase 7 interacting protein 1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1; RP3-407F17.2; TAB1; TAB1beta; TAK1-binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1
Símbolos de los genes TAB1
Especie del huésped Rabbit
Inmunógeno Protein corresponding to human TAB1 [aa1-aa370].
Método de purificación Protein A
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 10454, 66513
Especies diana Human, Mouse
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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