missing translation for 'onlineSavingsMsg'
Learn More
Learn More
STK4/MST1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
145.00€ - 410.00€
Especificaciones
Antígeno | STK4/MST1 |
---|---|
Concentración | 0.56 mg/mL |
Aplicaciones | Immunofluorescence, Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot |
Clasificación | Polyclonal |
Conjugado | Unconjugated |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
---|---|---|---|---|---|---|---|---|---|
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
16871785
|
Proteintech
22245-1-AP-20UL |
20 μL |
145.00€
20 microlitros |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
16861785
|
Proteintech
22245-1-AP-150UL |
150 μL |
410.00€
150 microlitros |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
Descripción
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.Especificaciones
STK4/MST1 | |
Immunofluorescence, Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
Unconjugated | |
Rabbit | |
Human, Mouse, Rat | |
Q13043, Q9JI11 | |
311622, 58231, 6789 | |
STK4/MST1 Fusion Protein Ag17738 | |
Primary | |
-20°C | |
STK4 |
0.56 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
KRS2, MST 1, MST1, serine/threonine kinase 4, STE20 like kinase MST1, STK4, YSK3 | |
Stk4 | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |
¿Detecta una oportunidad de mejora?Comparta una corrección de contenido
Corrección del contenido de un producto
Proporcione sus comentarios sobre el contenido del producto rellenando el siguiente formulario.
Título del producto
STK4/MST1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech