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Invitrogen™ SPTLC2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA531130
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Descripción
Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, mouse liver. Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (80%), Chicken (84%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. SPT2 is catalytically active but needs its related protein SPT1 for its stabilization and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum. As in the case with SPT1, mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from a loss of SPT activity as well as the accumulation of the atypical and neurotoxic sphingoid metabolite 1-deoxy-sphinganine.
Especificaciones
| SPTLC2 | |
| Polyclonal | |
| Unconjugated | |
| SPTLC2 | |
| AI173915; hLCB2a; HSN1C; KIAA0526; LCB 2; LCB2; LCB2a; long chain base biosynthesis protein 2; Long chain base biosynthesis protein 2a; mKIAA0526; NSAN1C; Pomt2; protein-O-mannosyltransferase 2; serine palmitoyltransferase 2; serine palmitoyltransferase long chain base subunit 2; serine palmitoyltransferase, long chain base subunit 2; serine palmitoyltransferase, subunit II; serine-palmitoyl-CoA transferase 2; SPT 2; SPT2; Sptlc2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 20773, 9517 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 0.41 mg/mL | |
| PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7 | |
| O15270, P97363 | |
| SPTLC2 | |
| Recombinant protein encompassing a sequence within the center region of human Serine palmitoyltransferase 2. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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