SOX10 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. SOX10 plays a central role in developing and maturing of glia. Specifically, SOX10 activates expression of myelin genes (such as DUSPP15 and MYRF) during oligodendrocyte (OL) maturation; thus, playing a central role in oligodendrocyte maturation and CNS myelination. Once induced MYRF cooperates with SOX10 to implement the myelination program. SOX10 is also a transcriptional activator of MITF acting synergistically with PAX3. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.