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  6. Invitrogen™ SOCS1 Recombinant Rabbit Monoclonal Antibody (6C6W1)

Invitrogen™ SOCS1 Recombinant Rabbit Monoclonal Antibody (6C6W1)

Código de producto. 30282851
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100 μL
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100 microlitros
20 microlitros
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Código de producto. 30282851 Proveedor Invitrogen™ N.º de proveedor MA558005

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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT.

The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
TRUSTED_SUSTAINABILITY

Specifications

Antígeno SOCS1
Aplicaciones ELISA, Immunohistochemistry (Paraffin)
Clasificación Recombinant Monoclonal
Clon 6C6W1
Concentración 1.00 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3
génica Socs1
N.º de referencia del gen O15524, O35716, Q9QX78
Alias de gen CIS1; Cish1; Cish7; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK2-binding protein; JAK-binding protein; Socs1; SOCS-1; SSI1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP3; TIP-3
Símbolos de los genes Socs1
Especie del huésped Rabbit
Inmunógeno A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOCS1 (NP_003736.1).
Método de purificación Affinity chromatography
Cantidad 20 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 12703, 252971, 8651
Especies diana Human, Mouse, Rat
Contenido y almacenamiento -20°C, Avoid Freeze/Thaw Cycles
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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