Invitrogen™ SLMAP Polyclonal Antibody

Descripción

Immunogen sequence: TTDAQMDEQD LNEPLAKVSL LKALLEEERK AYRNQVEEST KQIQVLQAQL QRLHIDTENL REEKDSEITS TRDELL Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 89%.

Sarcolemmal membrane associated protein (SLMAP) is a tail-anchored membrane protein involved in the docking and membrane fusion process via protein-protein interactions. Deregulation of SLMAP expression plays an important role in type 2 diabetes, and changes in SLMAP expression are linked to hyperglycemia and diabetes. SLMAPs are components of cardiac membranes and have been identified as a novel regulator of cardiac function. There are several isoforms of SLMAPs with varying molecular size (35, 45, 63, and 83-91 kDa) as a result of alternative splicing. The short 35- kDa isoform is predominantly expressed in cardiac and slow-twitch skeletal muscle, while the 83- to 91- kDa isoform is ubiquitous.