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Invitrogen™ SETD6 Monoclonal Antibody (GT688)

Descripción
Positive Control: K562, THP-1, HL-60 Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates Lys-310 of the NFκB p65 subunit of NFκB complex, leading to down-regulate NFκB transcription factor activity. SETD6-mediated methylation renders NFκB p65 inert and attenuates NFκB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NFκB-mediated inflammatory responses in diverse cell types.
Especificaciones
Especificaciones
| Antígeno | SETD6 |
| Aplicaciones | Immunohistochemistry (Paraffin), Western Blot |
| Clasificación | Monoclonal |
| Clon | GT688 |
| Concentración | 1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 20% glycerol and no preservative; pH 7 |
| génica | SETD6 |
| N.º de referencia del gen | Q8TBK2 |
| Alias de gen | 0610039J04Rik; 3110004G14Rik; AI413388; C76402; N-lysine methyltransferase SETD6; RGD1560538; SET domain containing 6; SET domain-containing protein 6; SETD6 |
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Título del producto
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