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Invitrogen™ SCUBE2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA556278
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Descripción
Immunogen sequence: SGIHLSSDVT TIRTSVTFKL NEGKCSLKNA ELFPEGLRPA LPEKHSSVKE SFRYVNLTCS SGKQVPGAPG RPSTPKEMFI TVEFELETNQ KEVTASCDLS CIVKRTEKRL RKAIRTLRKA VHREQFHLQL SGMNLDVAK Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 83%.
SCUBE2 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and are expressed in embryonic neuroectoderm and vascular epithelium. SCUBE2 is a close homolog to SCUBE1 and can form a heterodimeric complex with SCUBE1. SCUBE2 is thought to participate in the Hedgehog signaling pathway by specifically interacting with Sonic Hedgehog (SHH) and the receptor PTCH1, enhancing the SHH signaling activity in the raft microdomains of the plasma membrane, and may thus play important roles in organ development and tumor progression.
Especificaciones
| SCUBE2 | |
| Polyclonal | |
| Unconjugated | |
| SCUBE2 | |
| CEGB1; CEGF1; CEGP1; Protein CEGP1; RGD1563998; Scube/You; SCUBE2; Scube2-ps1; signal peptide; Signal peptide, CUB and EGF-like domain-containing protein 2; signal peptide, CUB domain and EGF like domain containing 2; signal peptide, CUB domain, EGF-like 2; signal peptide, CUB domain, EGF-like 2, pseudogene 1 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 57758 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q9NQ36 | |
| SCUBE2 | |
| Recombinant protein corresponding to Human SCUBE2. Recombinant protein control fragment (Product #RP-88796). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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