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Invitrogen™ SCIN Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA554225
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Descripción
Immunogen sequence: LKANQVATGI RYNERKGRSE LIVVEEGSEP SELIKVLGEK PELPDGGDDD DIIADISNRK MAKLYMVSDA SGSMRVTVVA EENPFSMAML LSEECFILDH G Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 87%.
The SCIN gene, also known as scinderin, encodes for a calcium-dependent actin filament-severing protein that is involved in the regulation of the cytoskeleton. It plays a significant role in actin filament dynamics, influencing cellular processes such as cell shape, motility, secretion, and division. SCIN has been identified as a novel oncogene, with its abnormal expression strongly correlated to various cancers, including glioma and uterine corpus endometrial carcinoma. Specific mutations like S673F and S381Y in SCIN are linked with poor prognosis and are potential targets for cancer diagnosis, prognosis, and treatment strategies.
Especificaciones
| SCIN | |
| Polyclonal | |
| Unconjugated | |
| SCIN | |
| Adseverin; AW545522; Gelsolin-like protein; KIAA1905; SCIN; Scind; Scinderin | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 85477 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 0.7 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q9Y6U3 | |
| SCIN | |
| Recombinant protein corresponding to Human SCIN. Recombinant protein control fragment (Product #RP-92603). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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