Invitrogen™ RWDD3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Marca: Invitrogen™ PA520821

Código de producto. 12898992

530.00€ / 100 microgramos

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Descripción

A suggested positive control is mouse kidney tissue lysate. PA5-20821 can be used with blocking peptide PEP-0935.

RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Ikappa-Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikappa-Beta increased stability. RSUME-enhanced sumoylation of Ikappa-Beta leads to the inhibition of NF-kappa-Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

Especificaciones

Antígeno	RWDD3
Clasificación	Polyclonal
Conjugado	Unconjugated
génica	RWDD3
Alias de gen	2510027J23Rik; 3110037C01Rik; AI035684; AI662458; pituitary tumor X2CR1 protein; RSUME; RWD domain containing 3; RWD domain-containing protein 3; RWD domain-containing sumoylation enhancer; RWD-containing sumoylation enhancer; Rwdd3; X2cr1
Especie del huésped	Rabbit
Método de purificación	Antigen Affinity Chromatography
Estado normativo	RUO
ID de gen (Entrez)	25950, 65026, 66568
Contenido y almacenamiento	Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Formulario	Liquid

Aplicaciones	Western Blot
Concentración	1 mg/mL
Formulación	PBS with 0.02% sodium azide
N.º de referencia del gen	P0C7N0, Q8VIL2, Q9Y3V2
Símbolos de los genes	RWDD3
Inmunógeno	A 17 amino acid peptide from near the amino terminus of human RWDD3.
Cantidad	100 μg
Primario o secundario	Primary
Especies diana	Human, Mouse, Rat
Tipo de producto	Antibody
Isotype	IgG

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Invitrogen™ RWDD3 Polyclonal Antibody

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