Invitrogen™ RUNX2 Polyclonal Antibody

Descripción

PA1-41519 detects RUNX2 in chicken, chimpanzee, new world monkey, equine, human and mouse samples. This antibody is predicted to react with rat, pufferfish, zebrafish, and xenopus based on sequence homology.

RUNX2, a nuclear protein, is a member of the RUNX family of transcription factors and has an Runt DNA-binding domain. It is essential for membranous and endochondral bone formation. It not only regulates osteoblastic differentiation and skeletal morphogenesis but also acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer and with more affinity, as a subunit of a heterodimeric complex. It plays a critical role in increasing TGFBR1 expression by osteoblasts and functions in cooperation with DLX5 or a related factor to activate osteoblast-specific gene expression. Mutations lead to disorders in bone development like cleidocranial dysplasia (CCD).