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  6. Invitrogen™ RT1.Bu Monoclonal Antibody (OX-3), PE

Invitrogen™ RT1.Bu Monoclonal Antibody (OX-3), PE

Código de producto. 15368320
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Cantidad:
200 μg
50 μg
Tamaño de la unidad:
200 microgramos
50 microgramos
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15368320 50 μg 50 microgramos
15378320 200 μg 200 microgramos
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Código de producto. 15368320 Proveedor Invitrogen™ N.º de proveedor MA517418

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Descripción

Mouse Monoclonal Antibody

anti-rat RT1.Bu monoclonal antibody recognizes a polymorphic determinant on rat Ia present on Lewis, Wistar, and AO rat strains (although it is apparently expressed in lower amounts in AO rats) but not BN, DA, or PVG/c strains. This antibody also cross-reacts with mouse strains (MHC haplotypes b and s) and analysis of recombinant mouse strains shows that the determinant maps to the I-A region and correlates with mouse Ia specificity 9. Recognizes Ia antigens on approximately 18% of thymocytes but does not significantly label the majority of peripheral T lymphocytes. Thus, this antibody is particularly useful for distinguishing Ia positive cells from different rat strains and has been used in the recognition of cells of donor origin in bone marrow reconstituted radiation chimeras.

RT1.Bu is a gene located within the major histocompatibility complex (MHC) region of the rat genome, specifically part of the RT1 complex. The RT1 complex in rats is analogous to the human HLA and mouse H2 MHC regions and encompasses a variety of class I and class II genes involved in antigen presentation. RT1.Bu is one such class I MHC gene, encoding a protein essential for the presentation of endogenous peptides to cytotoxic T cells. This interaction is vital for the immune system's ability to recognize and eliminate infected or malignantly transformed cells. The RT1.Bu gene is crucial for studying immune responses, particularly in transplantation immunology and autoimmune disease models, due to its role in histocompatibility and immune regulation.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno RT1.Bu
Aplicaciones Flow Cytometry
Clasificación Monoclonal
Clon OX-3
Concentración 0.1 mg/mL
Conjugado PE
Formulación PBS with 4-5mg/mL BSA and 0.02% sodium azide
génica RT1-Ba
N.º de referencia del gen P20037
Alias de gen activated B cell RT1Bl alpha chain; BA1; MHC class II antigen RT1.B alpha chain; rano class II histocompatibility antigen, B alpha chain; rat class I Bu; RT1 class II antigen, Ba chain; RT1 class II, locus Ba; RT1-B alpha; RT1-Ba; RT1-Bu
Símbolos de los genes RT1-Ba
Especie del huésped Mouse
Inmunógeno Rat thymocyte membrane glycoprotein.
Método de purificación Protein G
Cantidad 50 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 309621
Especies diana Rat
Contenido y almacenamiento 4°C, do not freeze
Tipo de producto Antibody
Formulario Liquid
Isotype IgG1
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