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Invitrogen™ RNF41 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA575157
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Descripción
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. Nrdp1, also known as RNF41 (RING finger protein 41), SBBI03 or FLRF, is a 317 amino acid protein that contains one RING-type zinc finger and one SIAH-type zinc finger. Expressed in testis, ovary and prostate, Nrdp1 functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, Nrdp1 interacts with ErbB-3 and UBPY, thereby targeting them for proteasomal degradation.
Especificaciones
| RNF41 | |
| Polyclonal | |
| Unconjugated | |
| RNF41 | |
| 2210404G21Rik; 4930511A05Rik; 4933415P08Rik; D10Ertd722e; E3 ubiquitin-protein ligase NRDP1; fetal liver ring finger; FLRF; neuregulin receptor degradation protein-1; Nrdp1; RING finger protein 41; ring finger protein 41, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase NRDP1; Rnf41; SBBI03 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 10193, 362814, 67588 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q8BH75, Q9H4P4 | |
| RNF41 | |
| Synthetic peptide corresponding to amino acids 100-150 of Human RNF41. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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