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Invitrogen™ RGMA Recombinant Rabbit Monoclonal Antibody (24GB1320)
Rabbit Recombinant Monoclonal Antibody
Marca: Invitrogen™ MA557221
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Descripción
RGMA Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Especificaciones
| RGMA | |
| Recombinant Monoclonal | |
| 0.67 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q6PCX7, Q96B86 | |
| RGMA | |
| A synthesized peptide derived from human RGMA (aa 401-435). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 24GB1320 | |
| Unconjugated | |
| RGMA | |
| BC059072; C230063O06; repulsive guidance molecule; repulsive guidance molecule A; repulsive guidance molecule family member a; RGM; RGM domain family member A; RGM domain family, member A; RGMA | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 244058, 308739, 56963 | |
| -20°C | |
| Liquid |
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