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SMAD2 (phospho S467), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic phosphopeptide of SMAD2.
Marca: Abnova PAB7759.100uL
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Descripción
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]
Especificaciones
| SMAD2 | |
| Polyclonal | |
| Unconjugated | |
| Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user. | |
| SMAD2 | |
| SMAD2 | |
| Synthetic phosphopeptide corresponding to residues surrounding S467 of human SMAD2. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| Rabbit polyclonal antibody raised against synthetic phosphopeptide of SMAD2. | |
| In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide) | |
| JV18/JV18-1/MADH2/MADR2/MGC22139/MGC34440/hMAD-2/hSMAD2 | |
| Rabbit | |
| Immunoaffinity purification | |
| RUO | |
| 4087 | |
| Store at -20°C. Aliquot to avoid repeated freezing and thawing. |
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Título del producto
For Research Use Only
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