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RAD17 Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic peptide of RAD17.
Marca: Abnova PAB27091.100uL
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Descripción
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq
Especificaciones
| RAD17 | |
| Polyclonal | |
| Unconjugated | |
| Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) Immunofluorescence (1:50-1:200) The optimal working dilution should be determined by the end user. | |
| RAD17 | |
| RAD17 | |
| A synthetic peptide corresponding to human RAD17. | |
| 100 μL | |
| Primary | |
| RAD17 polyclonal antibody detects endogenous levels of RAD17 protein. | |
| Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
| Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot | |
| 1 mg/mL | |
| Rabbit polyclonal antibody raised against synthetic peptide of RAD17. | |
| In PBS, pH 7.2 (0.05% sodium azide) | |
| CCYC/FLJ41520/HRAD17/R24L/RAD17SP/RAD24 | |
| Rabbit | |
| Antigen affinity purification | |
| RUO | |
| 5884 | |
| Human, Mouse | |
| Liquid |
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Título del producto
For Research Use Only
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