Invitrogen™ PSPN Monoclonal Antibody (275508)

Descripción

In Western blots, no cross-reactivity with recombinant human (rh) AgRP, rhArtemin, rh beta IG-H3, rhCripto-1, recombinant drosophila Decapentaplegic, rhGDNF, rhLAP, rhLatent TGF-beta 1, rhLefty-A, rhMIS, rhNeurturin, recombinant mouse (rh) Nodal, rmPersephin, rhTGF-alpha, rhTGF-beta 1, rhTGF-beta 1.2, rhTGF-beta 2, rhTGF-beta 3, or recombinant amphibian TGF-beta 5 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Persephin is a disulfide-linked, homodimeric, neurotrophic factor structurally related to GDNF, artemin, and neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken, and was later shown to be the preferential binding subunit for persephin. Persephin promotes the survival of ventral midbrain dopaminergic neurons and motor neurons after sciatic nerve oxotomy, and, like GDNF, promotes ureteric bud branching. However, in contrast to GDNF and neurturin, persephin does not support the survival of peripheral neurons.